Faculty
- Dah-eun (Chloe) Chung
- Assistant Professor
This email address is being protected from spambots. You need JavaScript enabled to view it. - Office: D417 Nelson Labs
- Click for Research Website
- Biography:
Postdoctoral Training - Baylor College of Medicine (BCM), Advisor: Huda Y. Zoghbi, M.D.
Ph.D. in Neuroscience - Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS), Advisor: Leonard Petrucelli, Ph.D.
B.A. in Biochemistry - Washington University in St. Louis, Minor in Philosophy-Neuroscience-Psychology
Funding & Fellowships:
2023-2025 Alzheimer's Disease Research Postdoctoral Fellowship BrightFocus Foundation, PI
2021-2022 Center for Alzheimer’s and Neurodegenerative Diseases (CAND) Scholar Baylor College of Medicine
2013-2015 Dean’s Fellowship Mayo Clinic Graduate School of Biomedical Sciences
2011 Summer Undergraduate Research Fellowship Howard Hughes Medical Institute
Honors & Awards:
[2023] Dean’s Award of Excellence School of Biomedical Sciences, BCM
[2022] Research Award KSEA West Gulf Coast Regional Conference
[2022] Excellence in Research Award KSEA Texas Biomedical Trainee Symposium
[2017] Predoctoral Travel Award MCGSBS
[2017] Best Poster Award MCGSBS Annual Student Research Symposium
[2013] Conference Scholarship Mayo Clinic Center for Individualized Medicine
- Research Group: Neuroscience
- Research Interests:
Neurodegeneration; Alzheimer’s disease; Tau biology and tauopathies; Molecular neuroscience; Mechanisms of protein aggregation; Regional brain vulnerability; Big tau isoform and protective molecular pathways.
Publications
1. Chung DC, Deng X, Yalamanchili H, Revelli JP, Han A, Tadros B, Richman R, Dias M, Naini FA, Boeynaems S, Hyman BT, and Zoghbi HY. (2024) “The big tau splice isoform resists Alzheimer’s-related pathological changes.” bioRxiv. (Manuscript In Revision.)
- Featured in:AlzForum,The Transmitter, GWAS Stories
2. Tadros B, Kim J, Xhako E, Chung DC, Li Y, Kim Y, Liang YH, Jung SY, Zoghbi HY. “LMO7 modulates tau levels by regulating CHIP-BAG5 interplay: Novel insights into tauopathy mechanisms.” In preparation.
3. Kim J, Tadros B, Liang YH, Kim Y, Lasagna-Reeves C, Sonn JY, Chung DC, Hyman BT, Holtzman DM, Zoghbi HY. (2024) “TYK2 regulates tau levels, phosphorylation, and aggregation in tauopathy model mice”. Nature Neuroscience 27(12): 2417-2429.
4. Chung DC, Roemer S, Petrucelli L, and Dickson DW. (2021) “Cellular and pathological heterogeneity of primary tauopathies.” Molecular Neurodegeneration 16(1): 57.
5. Chung DC, Carlomagno Y, Cook CN, Jansen-West KR, Daughrity L, Lewis-Tuffin LJ, Castanedes-Casey M, DeTure M, Dickson DW*, and Petrucelli L*. (2019) “Tau Exhibits Unique Seeding Properties in Globular Glial Tauopathy.” Acta Neuropathologica Communications 7(1): 36. (* Co-corresponding authors.)
6. Carlomagno Y, Chung DC, Yue M, Kurti A, Avendaño NM, Castanedes-Casey M, Ross KM, Jansen-West K, Daughrity L, Tong J, Phillips V, Rademakers R, DeTure M, Fryer JD, Dickson DW, Petrucelli L, Cook CN. (2019) “Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant.” Acta Neuropathologica Communications 7(1): 10.
7. Chung DC*, Stankowski JN*, and Petrucelli L. (2017) “Neurobiology of FTD: Animal and Human Studies.” Charney & Nestler's Neurobiology of Mental Illness 5th edition. Charney DS, Nestler EJ, Sklar P, Buxbaum JD. Eds. (* Equal contribution.)
8. Carlomagno Y, Chung DC, Yue M, Castanedes-Casey M, Madden BJ, Dunmore J, Tong J, DeTure M, Dickson DW, Petrucelli L, and Cook C. (2017) “An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.” Journal of Biological Chemistry 292(37): 15277-15286.
9. Kim J, Yoon H, Chung DE, Brown JL, Belmonte KC, and Kim J. (2015) “miR-186 is decreased in aged brain and suppresses BACE1 expression.” Journal of Neurochemistry 137(3): 436-45.
- Recruiting New Research Assistants: Not Currently Recruiting